What is Dry Eye?

Once viewed as a painful nuisance, dry eye disease (DED) today is considered a “critical and significant public health issue” in the United States. The quality of vision and life is compromised by Ocular Surface Disease such as “Dry Eyes”. Center for Sight is proud to include nationally recognized Dr Paul Karpecki, and his hand picked and trained team in advanced clinical care and research, to offer the most advanced care of OSD care in the warmth of a patient centric environment.

Symptoms include:

  • watery eyes
  • sensitivity to light
  • a burning sensation in the eyes
  • eye grittiness
  • blurred and fluctuating vision

…all of which may negatively impact quality of life.1,2

There are two types of DED—aqueous-deficient and evaporative. Evaporative DED is more common than aqueous-deficient dry eye, but more than one-third of patients will have a combination of both types.8

Risk Factors

Risk factors for DED development are myriad and can be environmental (use of air conditioning/fans, exposure to smoking, low humidity, dry climates, and windy conditions) or medical (blood pressure medications, antidepressants, glaucoma medications, rheumatoid arthritis, and Sjögren’s syndrome, lupus, diabetes, among others).9

About 30% of the 140 million people who wear contact lenses worldwide discontinue use due to dryness and eye discomfort. People who wear contacts are four times more likely to develop DED than those who do not. 2

One of the greatest risk factors, however, is gender. DED is more common in women than men, particularly in women with autoimmune disease who are over age 50.2 Women also are diagnosed with DED at a younger age than men.

Two large epidemiological studies in North America, the Women’s Health Study and the Physician’s Health Studies, showed a statistically significant, age-adjusted 70% increase in risk of DED among women.

The Beaver Dam Study showed that the prevalence of DED is 50% higher among women than men.10 This is likely due to the decrease in natural tear production that occurs from hormonal changes from pregnancy, use of birth control pills, or menopause.

Trattler et al. found that the incidence of DED was higher than anticipated in a real-world setting of patients scheduled to undergo cataract surgery; while patients showed clinical signs of DED and 22% had been previously diagnosed with DED, 30% had at least occasional complaints. 11

DED impacts more women, who experience symptoms and pain that are more severe.

The epidemiology of DED is also changing. DED is now impacting younger patients across both sexes, attributed mostly to the rise in smartphone and computer use.2,3 Handheld electronic device use is now recognized as a risk factor for DED development because it leads to decreased blink rates, and it causes the tear film to evaporate faster.14 Smartphones may also be to blame for the increase in DED incidence.

A recent survey revealed that 66% of ophthalmologists report patients presenting with screen-related eye problems, and 88% point to smartphone use as the cause of rising DED prevalence.15

Decreased work productivity is the most significant indirect cost to DED patients, given that mild cases of DED will progress and become severe if left untreated, increasing patients’ dependence on artificial tears.17

It is clear that DED has a substantial and negative impact on those affected, but also on healthcare systems.



  1. Miljanovic B, Dana R, Sullivan DA, Schaumberg DA. Impact of dry eye syndrome on vision-related quality of life. Am J Ophthalmol 2007;143(3):409-15.
  2. Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II Epidemiology Report. The Ocular Surface 2017;15(3):334-65.
  3. Farrand KF, Fridman M, Stillman IO, Schaumberg DA. Prevalence of Diagnosed Dry Eye Disease in the United States Among Adults Aged 18 Years and Older. Am J Ophthalmol 2017;182:90-8.
  4. Adler R. Dry eye syndrome: Symptoms and causes. All About Vision, 2017.
  5. Douty M. Market Scope: Global Dry Eye Products Market to Total $6.2 Billion in 2023. Available at: https://www.market-scope.com/pages/news/3020/global-dry-eye-products-mar… Accessed June 15, 2019.
  6. Asbell PA, Spiegel S. Ophthalmologist perceptions regarding treatment of moderate-to-severe dry eye: results of a physician survey. Eye Contact Lens2010;36(1):33-8.
  7. Chalmers RL, Begley CG, Edrington T, et al. The agreement between self-assessment and clinician assessment of dry eye severity. Cornea2005;24(7):804-10.
  8. Lemp MA, Crews LA, Bron AJ, et al. Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea 2012;31(5):472-8.
  9. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5(2):93-107.
  10. Sullivan DA, Rocha EM, Aragona P, et al. TFOS DEWS II Sex, Gender, and Hormones Report. Ocul Surf 2017;15(3):284-333.
  11. Trattler WB, Majmudar PA, Donnenfeld ED, et al. The Prospective Health Assessment of Cataract Patients’ Ocular Surface (PHACO) study: the effect of dry eye. Clin Ophthalmol 2017;11:1423-30.
  12. Schaumberg DA, Uchino M, Christen WG, et al. Patient reported differences in dry eye disease between men and women: impact, management, and patient satisfaction. PLoS One 2013;8(9):e76121.
  13. Um SB, Yeom H, Kim NH, et al. Association between dry eye symptoms and suicidal ideation in a Korean adult population. PLoS One2018;13(6):e0199131.
  14. Moon JH, Kim KW, Moon NJ. Smartphone use is a risk factor for pediatric dry eye disease according to region and age: a case control study. BMC Ophthalmol 2016;16(1):188.
  15. Hoffman M. Survey Data Reveals Major Concerns About Screen Use, Chronic Dry Eye. MD Magazine, 2018.
  16. McDonald M, Patel DA, Keith MS, Snedecor SJ. Economic and Humanistic Burden of Dry Eye Disease in Europe, North America, and Asia: A Systematic Literature Review. Ocul Surf 2016;14(2):144-67.
  17. Craig JP, Nelson JD, Azar DT, et al. TFOS DEWS II Report Executive Summary. Ocul Surf 2017;15(4):802-12.

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